There are thousands of genetic diseases that together affect Millions of Americans. Many of these people feel alone – even orphaned – because there are so few with whom they can share their experience. The science that inspired these dress melds experimental and computational biology to identify drugs that could be repurposed to treat genetic diseases. The design is inspired by the power and independence sparked within rare diseases patients by new technologies and treatments. The red heart of the dress represents the blood vessels that hold the endothelial cells that are key to the inspiring technology. The black bra is composed of a printed three-dimensional matrix that further evokes the blood vessels that incorporate into all tissues and exchange nutrients. The model emerges from a green cage and a black train, which evoke actin stress fibers and emergence from disease to freedom. The shape and texture of the dress further reinforce the intricacy and complication associated with each rare genetic disease, but also the elegance and power that can emerge from them.